Welcome to
the CRP Clinic
Renewing Hope, Fulfilling Dreams, Embracing New Life.
We specialise in advanced treatments to address pregnancy loss and fertility challenges.
I'm looking
for help with miscarriages
I need
help to get pregnant
I want to
check on my baby's health
The CRP Clinic was founded by Professor Hassan Shehata, a renowned Consultant Obstetrician and Gynaecologist, specialised in Maternal Medicine.
With extensive training and expertise, focusing on recurrent miscarriages and pregnancy complications, Professor Shehata is dedicated to delivering the highest standard of care to our patients. His passion for improving reproductive health and his commitment to excellence have shaped the values and principles that define CRP Clinic.
Miscarriages
Miscarriages can occur at any stage of pregnancy and leave couples feeling overwhelmed and heartbroken. If you have experienced two or more consecutive pregnancy losses, known as recurrent miscarriages, we recognise the unique challenges you face.
Our team offers comprehensive testing and personalised treatment plans tailored to your specific needs. Our goal is to identify the root causes behind recurrent miscarriages and develop a customised approach to optimise your chances of a successful pregnancy.
Causes
Immune System Issues
Overactive immune factors like antinuclear antibodies (ANA) and thyroid antibodies, such as thyroid peroxidase (TPO) thyroid thyroglobulin antibodies (TTG) and thyroid stimulating hormone receptor antibodies (TSH-RAB), have also been associated with an increased risk of miscarriage, indicating a potential role of an overactive immune system in pregnancy loss.
Hormonal Imbalances
Polycystic Ovary Syndrome (PCOS) is a condition that can hinder successful pregnancies. Studies have revealed a link between PCOS and recurrent miscarriages, potentially attributed to factors like insulin resistance, elevated insulin levels, and heightened androgen levels often observed in PCOS.
Thyroid problems can also elevate the risk of miscarriage. Although the precise mechanisms are not fully understood, thyroid hormones are crucial for the development of various bodily tissues. Abnormal thyroid hormone levels can negatively impact fertility and pregnancy outcomes.
Abnormalities in the Womb
Issues related to the neck or structure of the uterus can contribute to pregnancy loss mainly in the second trimester after 14 weeks gestation.
Cervical incompetence refers to a weakened cervix that may struggle to support the growing fetus as the pregnancy progresses. This condition can affect women who have experienced late miscarriages or premature deliveries. Additionally, invasive treatments of the cervix for abnormal smear tests can increase the risk.
Womb malformations are another potential cause of miscarriage. These congenital conditions can vary in type and severity, including uterus didelphys, unicornuate uterus, bicornuate uterus (heart-shaped), and septate uterus. It remains unclear whether these malformations directly cause recurrent miscarriages and surgical interventions to correct them must be carefully considered.
Polyps and fibroids, non-cancerous growths in the womb could lead to failed implantation and, rarely, miscarriages. In some cases, surgical removal of fibroids may be necessary.
Infections
Bacterial Vaginosis (BV) has been associated with late miscarriages, premature deliveries, and post-delivery womb infections. BV occurs due to a disruption in the normal vaginal bacteria balance and is the most common cause of vaginal discharge among women of childbearing age.
Symptoms of BV may include thin white or grey discharge, a distinct fishy odour that intensifies after intercourse, genital area itching or irritation, and a burning sensation during urination. Diagnosis confirmation typically involves a vaginal swab and antibiotics are prescribed to treat BV once it is confirmed.
Group-B Streptococcus (GBS) is one of the many bacteria that normally live in our bodies and which usually cause no harm. GBS may be passed from person to person through direct physical contact. It is not a sexually transmitted disease. Testing for GBS is not routinely offered to all pregnant women in the UK. There is evidence that group B Strep can cause late miscarriage (death of the baby between 14 and 24 weeks of pregnancy) and stillbirth (death of the baby after 24 weeks of pregnancy up until the baby is born). We don’t understand why group B Strep causes stillbirths or late miscarriages in some babies but not others. However, thankfully stillbirths are relatively uncommon in the UK, and group B Strep is not a common cause of them, accounting for around 1% of all stillbirths before labour in high-income countries. So, it is rare that someone carrying GBS will have a stillbirth or late miscarriage caused by GBS. We’re not aware of any evidence that group B Strep causes earlier miscarriages (before 14 weeks of pregnancy).
High Sperm DNA Fragmentation
High levels of sperm DNA damage have been linked to an increased risk of miscarriage and poorer pregnancy outcomes, whether conception occurs naturally or through assisted reproductive techniques.
At our clinic, we offer a test to assess DNA damage in sperms. Men are advised to ejaculate 2-3 times within the week leading up to the test but abstain from sexual activity for 48 hours before the test. The sperm sample is sent to a laboratory in Copenhagen for analysis, preserved in liquid nitrogen.
Abnormal results from the test usually prompt a consultation with a urologist for further evaluation. Several factors can contribute to high DNA fragmentation, such as excess weight, smoking, infections, elevated temperatures, exposure to heavy metals, chemotherapy, certain medications, and varicocele (enlarged veins in the scrotum). It is crucial to investigate and address these factors to improve sperm health and reduce the risk of miscarriage.
If treatment is recommended, a complimentary repeat test is offered after 3 to 6 months to assess the impact of the intervention on sperm integrity. To ensure availability, we advise scheduling the appointment in advance.
Chronic Histiocytic Intervillositis (CHI)
Autoimmune or allergic phenomena were identified and treatment include immune therapy of different kinds and for different durations. The diagnosis is a histopathology one and include idiopathic inflammatory lesion, intervillous space location, extensive maternal infiltration of inflammatory mononuclear cells (monocytes, lymphocytes, histiocytes) in particular CD68, intervillous fibrinoid deposits and trophoblast erosions of varying degree, diffuse (massive) or multifocal infiltration.
We understand that experiencing a miscarriage can be a lonely and isolating journey, we want you to know that you are not alone. Our caring and supportive team is here to provide you with the empathy, understanding, and expertise you need to navigate through this challenging time.
If you or a loved one has experienced recurrent miscarriages and are seeking compassionate care and support, we encourage you to reach out to us. Our dedicated team of specialists is available at both locations to provide comprehensive care tailored to your needs.
Assisted Conception
As a satellite clinic to Kings Fertility, we ensure that our patients receive the highest standard of care and access to cutting-edge fertility technologies.
Treatments We Offer
Superovulation
- Follicle Stimulation: Medications are administered to stimulate the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which help the ovaries produce more follicles. This medication is typically taken for a few days during the menstrual cycle.
- Ultrasound Assessment: Regular ultrasound monitoring is conducted to assess the size and number of follicles and adjust the medication dosage accordingly. The ultrasound scans also help determine the timing of ovulation triggers.
- Ovulation Induction: An injection of human chorionic gonadotropin (HCG) is given to trigger ovulation and the release of mature eggs.
- Timed Intercourse: Based on the ovulation trigger injection, timed intercourse is planned to optimise the chances of conception.
Intrauterine Insemination (IUI)
- Sperm Preparation: The male partner provides a semen sample, which is processed to isolate the healthiest and most viable sperm.
- Insemination: Using a small catheter, the prepared sperm is gently inserted into the uterus, optimising the chances of fertilisation.
- Post-Procedure: After the IUI procedure, the woman can resume normal activities immediately.
- For couples where the male partner has high sperm DNA fragmentation, we offer an advanced technique called microfluidic separation (Zymot). Zymot is a sperm selection device that isolates sperm with the least amount of DNA damage, potentially increasing the chances of successful pregnancy in eligible couples.
In Vitro Fertilisation (IVF)
The IVF procedure includes:
- Ovarian Stimulation: The woman receives hormone medications to stimulate the ovaries and produces multiple eggs. Blood tests and ultrasound scans are conducted to monitor follicle development and ensure the eggs are collected at the optimal time.
- Egg Retrieval: The eggs are collected using a guided needle aspiration procedure performed at our partner clinic, Kings Fertility.
- Fertilisation: The collected eggs are fertilised with prepared sperm in a laboratory dish. If fertilisation is successful, embryos start to develop and are monitored for two to five days. Embryos can also be cryopreserved (frozen) for future use.
- Embryo Transfer: A selected number of embryos are transferred to the uterus using a special catheter guided by ultrasound. This step is performed at our partner clinic, Kings Fertility.
- Pregnancy Test: Approximately two weeks after the embryo transfer, a pregnancy test is performed to confirm the success of the treatment.
Your fertility journey is not one you have to face alone. Our team is dedicated to providing ongoing support, guidance, and counselling throughout the entire process.
We are committed to being by your side, offering reassurance, answering your questions, and celebrating your milestones as you move closer to realising your dream of starting or growing your family.
Baby Scans
At CRP Clinic, we understand the importance of comprehensive care and support during pregnancy, especially when it comes to monitoring the health and development of your baby.
Our Fetal Medicine team utilises advanced ultrasound technology to provide a range of specialised scans and assessments to ensure the well-being of your baby. From early pregnancy to the third trimester, we offer a variety of fetal medicine services tailored to meet your specific needs.
| Feature | NHS | High-Street Scan Clinics |
CRP Clinic: Consultant-Led Fetal Medicine |
|---|---|---|---|
| Main Purpose | Routine screening offered to the general population | Reassurance scans and keepsake images | Comprehensive medical assessment of your baby |
| Who Performs the Scan | Sonographer | Sonographer | Consultant in Fetal Medicine |
| Appointment Length | Short and structured | Varies | Longer, unhurried consultation with time for discussion |
| Accurate Pregnancy Dating | ✅ Yes | ✅ Yes | ✅ Yes |
| Assessment of Baby’s Development | Basic checks | Very limited | Detailed and systematic anatomical assessment |
| Screening for Trisomy 21, 18 & 13 | ✅ Combined screening | ❌ Not offered | ✅ Combined screening ± NIPT available |
| Nuchal Translucency Measurement | ✅ Included | Variable | ✅ Specialist-level assessment |
| Early Detection of Major Structural Concerns | Limited by time and scope | ❌ Not designed for this | ✅ Advanced early anatomy review |
| Placental Assessment | Basic review | ❌ Not included | ✅ Detailed evaluation incl. Doppler studies |
| On-Site Blood Tests | ✅ Available | ❌ Not available | ✅ Available |
| Immediate Medical Interpretation | Limited | ❌ Not provided | ✅ Consultant-led explanation |
| Continuity of Care | Depends on local pathway | ❌ No medical follow-up | ✅ Ongoing consultant oversight |
| Follow-Up & Pregnancy Planning | According to NHS guidelines | ❌ Not provided | ✅ Individualised proactive planning |
Services We Offer
Nuchal Scans
Anomaly Scans
Also known as mid-pregnancy ultrasounds, anomaly scans are comprehensive and detailed examinations typically performed between 20 and 24 weeks of pregnancy. These scans play a vital role in detecting any structural abnormalities in the fetus, assessing the baby’s well-being, and evaluating the placenta and amniotic fluid.
Growth Scans
Cervical Scans
3D/4D Ultrasound
NIPT (or Non-Invasive Prenatal Diagnosis Testing)
The test identifies 99%, but not all, of the fetuses with Trisomy 21, 97% of fetuses with Trisomy 18 and 92% of fetuses with Trisomy 13. The NIPT test can be performed in women carrying one or two alive fetuses at any stage in their pregnancy from 10 to 32 weeks.
The results from the test will generally be available within one weeks and we will notify you as soon as we receive them by phone and email/letter. In about 5% of cases the test does not give a result. This is due to technical problems with the analysis of the sample and does not suggest that there is a problem with the baby. If you want you can have the test repeated (at no cost) and there is a 50% chance that the test will give a result.
If the NIPT test shows that there is a high risk that the fetus has Trisomy 21 or 18 or 13 it does not mean that the fetus definitely has one of these defects. If you want to be certain if the fetus has one of these defects you should have CVS or amniocentesis. If the NIPT test shows that there is a low risk (less than 1 in 10,000) that the fetus has Trisomy 21 or 18 or 13 it is unlikely that the fetus has one of these defects.
The NIPT test does not provide information on physical defects, such as heart or brain abnormalities and spina bifida, or fetal growth. It is therefore advisable that you still have nuchal ultrasound scans at 11-13 weeks and at 20-22 weeks to examine the fetal anatomy and at 32-36 weeks to examine the fetal growth.
Contact us today to schedule an appointment and let us be a part of your prenatal care journey.
Women's Health
Whether you’re seeking a routine check-up, a fertility assessment, or a private menopause clinic, our experienced team is here to provide personalised and routine care tailored to your needs.
Check-Ups and Assessments
Wellwoman Check-up
During this annual visit, our skilled and friendly gynaecologists will review your medical history, perform a thorough physical examination, including a pelvic ultrasound, and conduct relevant tests such as blood work. This comprehensive assessment allows us to identify any risks or concerns and provide appropriate preventive or diagnostic measures.
Fertility Check-up and Assessment
Hormonal tests and screenings for sexually transmitted diseases may also be recommended to gather a comprehensive understanding of your fertility potential. With this information, we can offer guidance, discuss any concerns, and explore potential treatment options if necessary.
Specialised Menopause Support
We offer a variety of treatment options to alleviate menopausal symptoms, such as hot flushes, mood swings, and vaginal dryness. Hormonal replacement therapy (HRT) is one effective treatment that can help manage these symptoms and reduce the risk of associated conditions like osteoporosis and heart disease. Our expert gynaecologists will work closely with you to develop an individualised treatment plan that addresses your specific needs and concerns.
Endometriosis Clinic
Endometriosis occurs when tissue similar to the lining of the uterus grows outside the womb, leading to symptoms such as pelvic pain, heavy menstrual bleeding, and fertility issues.
At our clinic, we offer a range of services aimed at effectively managing endometriosis and improving your quality of life. Our team of gynaecologists conducts thorough assessments to diagnose your condition and develop a personalised treatment plan tailored to your unique needs.
Treatment options may include medication to improve symptoms, hormonal therapy to regulate hormone levels, minimally invasive surgery to remove endometrial tissue, and fertility preservation strategies for those planning to conceive.
Advanced Gynaecological Scans
3D Scans
Saline Scans
Saline scans are particularly useful for detecting conditions such as polyps, fibroids, and uterine adhesions, which may contribute to infertility or recurrent miscarriages. By identifying these issues, we can develop targeted treatment strategies to address your gynaecological concerns and optimize your reproductive health.
HyFosy (Tubal Patency Check)
HyFosy is an effective method for evaluating tubal health and identifying blockages or abnormalities that may affect fertility. By confirming tubal patency, we can help determine the most appropriate fertility treatment options for you, whether it be natural conception or assisted reproductive techniques.
Surgical Procedures
Hysteroscopy
Hysteroscopy is particularly valuable for diagnosing and managing conditions such as uterine polyps, fibroids, adhesions (Asherman’s syndrome), and abnormal uterine bleeding. During the procedure, therapeutic interventions can be performed as necessary, including the removal of polyps, excision of adhesions, or endometrial biopsies for further evaluation. The procedure can be done under local anaesthesia, although we typically recommend sedation to enhance patient comfort during the process.
Manual Vacuum Aspiration (MVA)
Men's Health
We provide high-quality specialised care and support to promote men’s health and well-being. Our urologist specialises in men’s health, focusing on male fertility and overall well-being. We offer comprehensive assessments and tailored treatment plans to address male infertility concerns. Similar to our approach to women’s health, we also provide annual Wellman checks to proactively monitor men’s health and detect any potential issues.
Check-Ups and Assessments
Male Fertility Evaluation
Through advanced diagnostic techniques, we can identify potential causes of fertility issues and offer personalised treatment options. Lifestyle modifications, targeted therapies, and assisted reproductive techniques like IUI or IVF may be recommended based on individual needs and circumstances.
Wellman Check-up
During the visit, our experienced urologists conduct a thorough medical assessment, including a comprehensive medical history review. Vital signs, such as blood pressure, height, and weight, are measured.
We also offer a detailed testicular examination and, if necessary, a testicular ultrasound to assess testicular health. Additional blood tests, including PSA (Prostate-Specific Antigen), liver and kidney function tests, male and thyroid hormonal tests, full blood count, and diabetes screening, may be recommended to provide a comprehensive health assessment. A urine analysis may also be included as part of the evaluation process.
Low Testosterone Or Libido
Testosterone replacement is not recommended when a couple are planning to have children due to the negative impact on sperm production but alternative medication may be available that boosts the body’s own testosterone levels and the quality of sperm.
Erection Problems
Ejaculation Problems
Testicular Swellings
Men may experience testicular swellings that can be linked to fertility concerns, sometimes arising from conditions such as varicoceles or infections, which may impact sperm production and quality. While most cases are benign, persistent or painful swellings should be evaluated to rule out underlying issues such as hydroceles or, rarely, testicular cancer. Depending on the cause, treatments may include antibiotics, surgical intervention, or assisted reproductive techniques to improve fertility outcomes.
Urinary Symptoms and Prostate Health
Prostate cancer is very rare under the age of 50 but men with a strong family history or Afro-Caribbean origins may be more at risk. More commonly the prostate enlarges for benign reasons but the symptoms this cause can have a significant effect on quality of life. Infectious problems such as prostatitis can also give similar symptoms more commonly in younger men.
Appropriate and prolonged antibiotic treatment may be required but consideration of effects of infection and antibiotics on sperm production must also be considered.
At the Wellman Clinic, we are committed to providing high-quality care and support to promote men's health and well-being.
Our team of experts combines their skills and knowledge with a compassionate approach to ensure that each patient receives personalised attention and effective treatment options. By addressing male health concerns, including fertility issues and general well-being, we aim to empower men to take control of their health and lead fulfilling lives.
Pioneering approach
to fertility challenges
We promote cutting edge scientific medical approach to diagnose and treat miscarriages and failed IVF attempts.
High Success Rate
Our experienced team of specialists has achieved excellent success rates, with over 80% of our patients experiencing successful pregnancies following our tailored treatment plans.
Personalised care
Each patient we see is unique and we provide tailored strategies to address their specific circumstances and family planning goals.
Compassionate support
We understand that experiencing a miscarriage can be a lonely and isolating journey. We want you to know that you are not alone. Our caring and supportive team is here to provide you with the empathy, understanding, and expertise you need to navigate through this challenging time.
Holistic Care for Couples'
Health and Fertility
We understand the importance of addressing both men's and women's concerns when it comes to starting a family. We provide tailored Wellwoman & Wellman services along with thorough fertility screening and complementary therapies. Our aim is to support and improve overall health as couples embark on their journey to parenthood.
Key CRP Clinic Numbers
Recurrent Miscarriages
Live Birth Rate
IVF/ICSI
Clinical Pregnancy Rate
Live Birth Rate
Superovulation Program
Clinical Pregnancy Rate
Key Numbers
Latest CRP Clinic News
After experiencing three heartbreaking losses (two miscarriages and a TFMR due to anencephaly) we felt completely lost and unsure if we would ever become parents.
Finding the CRP Clinic and Professor Shehata in March 2022 changed everything for us.
After thorough testing, Professor Shehata discovered that my natural killer cells were elevated, and we began treatment with the CRP team.
For the first time in a long time, we felt hopeful again.
Throughout my pregnancy, we were mainly looked after by Miss Edge for our scans, and she was absolutely fantastic.
So kind, reassuring, and supportive during what was naturally an anxious time for us.
Thanks to their care we welcomed our beautiful rainbow daughter Luna in May 2023.
She is everything to us and has brought more joy into our lives than we ever thought possible.
When we decided to try for a second baby, returning to CRP felt like the most natural decision.
We saw Professor Shehata again in February 2025 and began treatment once more.
We were incredibly lucky to fall pregnant again and welcomed our baby boy, Liam, in December 2025.
We are endlessly grateful to Professor Shehata, Miss Edge, and the entire CRP team.
Everyone we encountered was compassionate, understanding, and truly dedicated to helping us.
Despite going through medical treatment, we always felt cared for and supported.
Quite simply, we would not have our two beautiful children without them.
We will be forever grateful to the CRP Clinic for helping make our family possible.
Camila & Liam
Hello CRP family,
I’ve been meaning to send this email for months now, but honestly, I kept putting it off because I just couldn’t find the right words to sum up how thankful we are.
How do you even begin to thank the people who helped make your dream come true? 😃
So… here goes!
Because of your help, your diagnosis, your support, and your treatment, we are now the incredibly proud parents of our beautiful rainbow baby — Scarlett Rose.
She’s the sweetest little character, full of personality already, and she’s made my dream of being a mummy even better than I ever imagined.
Before coming to CRP, I thought fertility appointments would feel daunting and clinical.
How wrong I was!
From the very first consultation to our final pregnancy scan with you at 20 weeks, you made every step of the journey feel clear, calm, and full of hope.
You explained our “unexplained” infertility, treated it, and gave us the greatest gift — our perfect little bean.
Every time I walked through your doors, I felt like I was walking into a warm, welcoming home.
You have this lovely family atmosphere that somehow melts away the nerves.
Our special thanks:
Dr. Edge — you’re pure sunshine in a lab coat.
You explained everything so positively, and those pregnancy scans… you spent ages getting the clearest photos, like you genuinely wanted us to have the best keepsakes possible.
It meant so much.
Professor Shehata — our superhero!
I first heard you on a podcast and instantly knew I needed to come to your clinic.
You spoke with such passion and common sense about finding and fixing the root cause of fertility struggles.
And after just one round of testing, you looked me in the eye and said, “We can treat this!”
And you did. 😃
Thank you for your brilliance, your belief, and your wonderfully quirky fashion sense — we are so grateful!
Geri — your free spirit and sense of humour kept me laughing even when I was feeling nervous.
Marianna — so sweet, caring, and somehow remembered my old test results without even checking the notes (super impressive!) which saved delays, extra cost and made me feel truly cared for.
The doctor who did the Nuchal scan (I can’t remember his name now, sorry!) you made us smile just by showing a glimpse of the real person behind the white coat. 🤘
Loved our chats!
Your team are really something special.
Every single one of the staff we met were brilliant.
And that gorgeous photo frame you gave us when we “graduated” — it now has pride of place in Scarlett’s nursery.
The rest of my pregnancy went smoothly, and even the C-section was a lovely experience.
Scarlett did have hip dysplasia at birth, but the little harness she wore for 2 months didn’t bother her a bit.
She’s now hip-healthy and zooming around soldier crawling at 6 months old.
She even sleeps with her arms over her eyes — exactly like she did in every scan picture you did for us! 🙈
We love her more than words can say, and we owe that to all of you.
Thank you from the bottom of our hearts for helping us bring the most magical little girl into our lives.
You should all be incredibly proud of the work you do — you don’t just help create families, you really change lives.
Sending big hugs from all three of us,
Sarah, Simon & Scarlett Rose 🌹 xx
If you’ve started reading about PRP, it’s likely your fertility journey hasn’t been simple. Maybe your IVF cycles haven’t worked as hoped. Maybe embryo transfers were cancelled because your lining didn’t develop well. Maybe you’ve heard this mentioned as a “next step” and you’re trying to understand whether it’s right for you.
We’d like to explain PRP clearly and honestly — what it is, where it may help, and where expectations need to be realistic.
What is PRP?
PRP stands for Platelet-Rich Plasma.
It’s prepared from a small sample of your own blood. That blood is processed to concentrate platelets — cells that naturally release substances involved in:
- Tissue repair
- Formation of new blood vessels
- Cellular healing and regeneration
These substances, known as growth factors, act like signals that help tissues respond and recover. PRP has been used in other areas of medicine for years, including orthopaedics and wound care. In fertility treatment, its role is still being studied.
Why is PRP Used in Fertility Care?
For an embryo to implant successfully, the uterine lining must:
- Reach adequate thickness
- Have good blood supply
- Be biologically receptive to implantation
PRP is being explored because its growth factors may help support tissue response and blood vessel development in the endometrium.
Research is ongoing. Some patients appear to benefit, while others do not. It is not a universal solution.
PRP For a Thin Uterine Lining
One of the main situations where PRP is considered is when the lining remains thin despite standard treatments such as oestrogen therapy.
Why Lining Thickness Matters
A poorly developing lining can be associated with lower implantation rates. However, thickness alone does not determine success – lining quality and embryo health are equally important.
What Studies Show
Some clinical studies have reported that in selected patients:
- PRP placed into the uterus may increase lining thickness
- Some patients subsequently achieve pregnancy
However:
- Many studies are small
- Not all are randomised or high-quality trials
- Results are not consistent for everyone
For this reason, PRP for thin lining is seen as a developing option, not routine treatment.
PRP For Repeated Implantation Failure
When good-quality embryos do not implant, it can be extremely difficult. Repeated implantation failure can involve multiple factors:
- Embryo chromosomal abnormalities
- Uterine conditions
- Hormonal balance
- Immune factors
- Sometimes, chance
PRP has been studied as a way to improve the uterine environment in these cases. Some research suggests it may support blood flow and influence implantation-related signals. Still, it does not address embryo genetic issues, which remain a major cause of failed implantation.
PRP may be considered in selected cases, particularly when there is concern about lining development or uterine receptivity.
PRP and Ovarian Function
PRP has also been discussed for low ovarian reserve or poor ovarian response. This involves injecting PRP into the ovaries.
At present:
- Research is at an early stage
- Evidence is limited
- This approach is considered experimental in most fertility settings
Patients should approach this option with careful counseling.
Is PRP Safe?
Because PRP uses your own blood, allergic reactions are unlikely, as long as it is performed in an appropriate medical setting.
Long-term fertility data are still evolving.
What PRP Can and Cannot Do
PRP is not:
- A guarantee of pregnancy
- A treatment for embryo chromosomal abnormalities
- A substitute for a full fertility evaluation
It may be considered when:
- The lining repeatedly does not develop adequately
- Standard approaches have not been successful
- There is a reasonable medical basis to focus on the uterine environment
PRP works, if at all, as part of a broader, individualised treatment plan.
Why Individual Assessment Matters
After repeated disappointments, it’s completely understandable to want to try everything available. However, additional treatments should always be chosen for a clear medical reason.
At CRP Clinic, we use add-on treatments only when they are appropriate for the individual, not simply because they are available.
A Final Note From Our Team
Needing more detailed investigations or advanced treatment does not mean you’ve done something wrong. Recurrent implantation difficulties and lining problems are complex medical issues, and they deserve thoughtful, specialist care.
PRP is one of several developing tools in fertility medicine. For some patients, it may play a role. The most important part of care, however, is a plan built around your specific history, based on current evidence and delivered with support throughout the process.
You do not have to make these decisions on your own.
We will be forever grateful to Professor Shehata, Ms Edge, Mr Jan and the nursing team at the CRP clinic. We now have a beautiful, healthy, 10 month old daughter who was very much born against the odds.
I came across Professor Shehata’s details on the Tommy’s charity website. He was also referenced quite a bit on an IVF messaging board that I followed. By this point, we had been trying unsuccessfully for a baby for 5 years.
I had had 5 IVF embryo transfers, including the last 2 with donor eggs and I had experienced 2 implantation failures and 3 early miscarriages. I knew that I had low egg reserve following cancer treatment some years earlier, but I also felt that something else was at play which was causing the early miscarriages. However, I felt I was getting nowhere when I raised this with my IVF clinic.
Professor Shehata was incredibly detailed in his testing and he diagnosed me with very high Natural Killer Cells. He also advised me to have key hole surgery to remove 9 fibroids which were outside the uterine cavity.
Some months after the surgery with Mr Jan, which was a complete success, I started a drug regime to suppress my Natural Killer cells and then had a 6th embryo transfer at my IVF clinic.
Following a positive pregnancy test, I was monitored throughout pregnancy by the CRP and they also treated me in the early stages of pregnancy for a subchorionic hematoma, which might otherwise have resulted in early miscarriage.
The level of care provided is exceptional and the kindness of the staff is also amazing. I wish that the work of the CRP could have a broader reach, as I believe many more women would benefit from their treatment. I also wish we had found Professor Shehata sooner and avoided some of the heartache of repeated IVF failure and early miscarriage.
I would recommend the clinic to anyone who has experienced similar issues.
In December 2022, I sadly suffered my third miscarriage. At that point, we decided it was time to get a second opinion.
We had consistently been told that the reason for our baby losses was due to my weight and that we were simply “unlucky.”
After doing some research, we found Professor Shehata at the CRP Clinic. From our very first appointment in January 2023 right through to today, the whole team have been amazing.
I was diagnosed with high NK cells and given a treatment plan. Without the CRP Clinic, our baby boy Teddy would not be here today.
Professor Shehata, Ms Edge, and Mr Jan are truly incredible at what they do. Geri and Marianna were also extremely supportive, especially during the IVF process.
Thank you all for everything you’re doing – we are so deeply grateful. Our little man is only here because of the care and treatment we received.
- How Reproductive Immunology focuses on the immune system’s role in pregnancy.
- Why recurrent miscarriage is not typically caused by chromosomal abnormalities.
- How investigation should begin after two miscarriages, or one if late.
- How Male factors are often overlooked in miscarriage investigations.
- How testing protocols vary between NHS and private sectors.
- Why Natural killer cells play a significant role in recurrent miscarriage.
- How IVF does not improve outcomes for recurrent miscarriage patients.
- Why medications like prednisolone may have immune modulation effects.
- How microbiome testing is an emerging area but lacks conclusive evidence.
Where do we start thanking Professor Shehata and the CRP Clinic for the most precious gift we could ever have dreamed of, our Son Charlie born 16/06/2024.
We first came to the CRP Clinic back in February 2022. With no clear reason as to why we suffered four miscarriages, we self referred to the NHS side of the Recurrent Miscarriage Clinic to try and determine the issue. Having been with them for a year and experiencing a further loss during this time, we clearly needed further help. This is where Professor Shehata and his team at the CRP Clinic came to our rescue.
Under the care of Professor Shehata and Dr Marianne Edge, having determined whilst with the NHS that the reason for the losses was due to a extreme level of NK Cells, they navigated us through different courses of medication in order to find the correct prescription for me.
Unfortunately we did suffer another loss during this process however they never gave up on us and persisted to get us back on track and make our dreams come true.
No longer than 2 months after the loss we were pregnant again. It was a surprise that I was able to fall so quickly but once again we was navigated through this frightful journey again.
The care and support we got from the clinic helped us push through each and every scan (fortnightly) before finally reaching the stage of 20 weeks when we were then released to be under the care of the NHS.
There are so many people that we need to thank. Dr Marianne Edge, who saw me for most of my scans, calmed me down each and every time, Geri, who held my hand and cried with me wanting this as much as us, Georgia, who would be the first face I would see at reception and would take the time to see how I was and if theres anything they can do and also Michaela, who answered all my emails with questions I had about worries, settled my mind on many occasions. Finally, Proffessor Shehata. We wouldn’t have a family without your knowledge and wisdom on the matter. I know I was his nemesis but with his persistence and patience we got our miracle little boy.
We will be back for number 2 in the near future!
We would like to say a HUGE thank you to the CRP Clinic for helping us bring our two beautiful sons, Finley and Dylan, into the world.
It wasn’t a simple journey for us. Our first appointment with Professor Shehata was in June 2021 after finding out we would need ICSI to get pregnant. Unfortunately, after several failed rounds and a miscarriage we did further tests which found I also had high NK cells. At the time, it felt like there was no light at the end of the tunnel but luckily, we were in the right place. Professor Shehata and his team stayed positive, told us to be patient (easier said than done!) and I started the complex immune protocol alongside ICSI. Our son, Finley, was born in November 2023.
We were in a lucky position that we had some embryos frozen so went back last year to try for a sibling, knowing there were no guarantees and it might take a while. Amazingly, it worked first time and our second son, Dylan, was born in June 2025.
Throughout the 4 years we’ve been at CRP, the staff have been fantastic, never giving up hope, holding our hands during the dark days and celebrating with us when we got good news. A special mention to Mr Jan, Dr Edge and Geri who have been our rocks.
We will be forever grateful to the clinic for making all our dreams come true and wouldn’t hesitate to recommend them to anyone who’s struggling with infertility.
Sarah, James, Finley and Dylan xx
After enduring the unimaginable heartache of a neonatal loss, two missed miscarriages, and seven chemical pregnancies, I had truly lost all hope of ever holding my own living baby. The emotional toll was immense, and I felt utterly broken. After 5 years of trying to find answers down the normal route and not getting any, I didn’t know what to do. Then, a friend recommended the CRP Clinic. It was a beacon of light in what had become a very dark and lonely journey.
Professor Shehata’s research and dedication helped find an answer to what was causing all the losses. I started the treatment that was recommended and became pregnant with my rainbow baby. With each visit to the clinic, Dr Edge’s empathy and guidance reassured me and she answered every question that I had.
Thanks to the incredible team at CRP Clinic, my husband and I are now proud parents to our beautiful rainbow baby. They helped us achieve our miracle, and for that, we will be eternally grateful. They are truly exceptional.
CRP Clinic Testimonials
We welcomed a healthy baby boy, Jack, on 23rd April 2024. Navigating a pregnancy after loss is an anxious time, but the staff at CRP are caring and offer advice and reassurance at every step. Dr Edge is simply amazing, and seeing our baby in 4D at our 10 week scan was a magical moment. We are so grateful to Professor Shehata, and your pioneering research and treatment into recurrent miscarriages. Without this, we would not have our son. We are forever grateful to you all.
Grace and Darren
Elaine and Ryan
Tess and Robin
From the moment we walked through their doors, CRP took charge of our journey with unwavering dedication and expertise. They not only provided medical care but also offered us emotional support every step of the way. Thanks to their guidance and skill, our dreams were realised, and we couldn’t be happier with the outcome. To anyone embarking on a similar journey, I wholeheartedly recommend CRP. Put your trust in them, and let them work their magic.
Kouroshi
I’m so thankful that we found the CRP Clinic: our initial appointment with Professor Shehata was the first time that we felt really listened to and detailed notes were taken about each pregnancy. Thorough testing uncovered three separate issues which were not picked up elsewhere. After starting treatment for high NK cells in January, I fell pregnant in April and gave birth to a beautiful baby girl in January. I have no doubt that her birth is a result of the testing, medication and advice that we received at the clinic.
L Wilson
We will be forever grateful to CRP Clinic for everything that they have done for us to get our baby here safely. After a missed miscarriage at 10 weeks and an ectopic pregnancy we didn’t have much hope that things would work out. We welcomed our beautiful baby boy in March and he wouldn’t be here without Professor Shehata’s work on reproductive immunology. The entire team at CRP went above and beyond for us. Dr Edge was amazing and a big support to us.
E Babmead
I have 2 beautiful babies from visiting Mr Shehata and his team on both separate occasions. We had 5 miscarriages when I did not have the treatment and can only deduct that the treatment was a huge success. I am very grateful for that. The journey is emotional and can be costly, my honest review is that you cannot expect to be counselled with part of your treatment and so you need to have any expectations of this aside.
Christine
The whole team at the CRP clinic have been incredible but we would like to take the opportunity to pay a particular thank you to Professor Shehata, Dr Edge, Professor Akolekar and all the midwife team who went above and beyond. We know that without their amazing help and kindness we would not be here today. We are also so grateful for Professor Shehata’s care during my wife’s ectopic pregnancy last year where he went above and beyond to ensure she was safe.
Chris
My husband and I have been patients with the CRP clinic since 2016 -2023. Professor Shehata and his team have gone above and beyond to help us achieve our dream of starting a family after so many medical problems and losses. We now have two beautiful children thanks to their tireless efforts to make this a success for us. They do everything to find the right medications and protocols to work with your medical issues, your body etc.
Lisa
We received excellent care throughout our IVF journey and cannot thank Mr Jan, Geri, Mr Shehata and the rest of the team for their care and attentiveness. I felt very safe and cared for, they took the time to offer me clear advice and I was offered a treatment plan based on the latest research and evidence based practice. We are so grateful for our healthy 4 month old son today, thanks to you.
Sarah and Bowie
I attended the CRP clinic after suffering from recurrent miscarriage at 8, 12 and 19 weeks. The pregnancy was successful and we had a healthy baby girl in October 2022. Dr Silva was my main doctor throughout the pregnancy and she was incredible at supporting parents who have been through loss. he midwives and nurses were extremely caring and the scans are all done very sensitively and in a style that is supportive for parents.
Julie
Mr Shehata is extremely knowledgeable and kind. He and his consultants, midwives and other staff are experts in dealing with anxious expectant mothers. The midwife line is a great service for questions outside regular appointments. I urge anyone suffering from unexplained pregnancy loss to book a consultation with Mr Shehata or to try to get an NHS referral. I’d say he’s a miracle worker and should be given a knighthood for services to women’s health.
Janie
After 5 losses I was starting to give up all hope of having a baby and being a mum. I wasn’t getting any answers as to why this kept happening. The clinic finally gave me the answers I needed and amazing support and I now have happy, healthy (and crazy) 2 and 4 year old boys. Forever grateful to the clinic and all the staff that made it possible.
Nicola
I’m a recurrent and late miscarriage sufferer. I was told these were “bad luck”. There was a reluctance to test and an even bigger reluctance to treat. I had to find my own way to your clinic. Thank goodness this clinic exists. I felt heard and I found hope. My littlest boy is here now because of this clinic and its willingness to treat! Thank you from the bottom of my heart. Finally there is some peace.
Kirsten
They gave me my little miracle. Within 4 weeks of being tested I was pregnant with my second daughter after having suffered 9 miscarriages. Dr Shehata is the most amazing person and the wider team couldn’t do enough to support me on my journey.
Victoria
The CRP Clinic
Meet The CRP Clinic Team
At CRP Clinic, we understand the emotional and physical challenges our patients face. That's why we have assembled a compassionate, empathetic, and responsive multidisciplinary team of specialists who collaborate to provide comprehensive care and support the moment you step into our clinic together with personalised attention and a warm, welcoming smile.
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Start Your Journey Now: Take the Next Steps with the CRP Clinic
Contact us now to schedule a consultation and take the first step towards a fulfilling and joyful journey of parenthood.
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Contact Us
Epsom Address
Bramshott House, 137-139 High Street, Epsom, KT19 8EH
Call Us
01372 232221 | 0208 4019928
Opening Hours
Monday to Friday,
9AM - 5PM
Download The App
CRP Clinic Mobile App is the official follow-up mobile application for CRP Clinic patients.
As a CRP patient, you will get daily reminders for your medications and clinic appointments dates.
The app will take you step by step through the different treatment phases, with each phase containing a daily medication schedule and other useful info.
