Clinic News
& Fertility Insights

Every fertility journey is different. Explore real patient success stories, supportive guidance and updates from the CRP Clinic team, designed to help patients feel informed, reassured and supported throughout treatment.

We started trying to have a baby just after we got married in the beginning of 2018. We fell pregnant relatively quickly but suffered a missed miscarriage just before the 12 week scan. We were told countless times that it was just one of those things and to just try again.

 

We fell pregnant again a few months later. This time there was so much anxiety around the pregnancy as we now knew what could happen but as we had been told it was very unlikely to happen again we tried to stay positive. We suffered another missed miscarriage early in the pregnancy. After our second loss we decided to speak to an obstetrician privately. She assured us that given our age and health there should be no reason why the next pregnancy wouldn’t work out. As a precaution she prescribed us progesterone pessaries and low dose aspirin from the next positive pregnancy test and we left feeling like maybe this could be the answer.

 

Again we fell pregnant and the drugs seemed to be working. We passed the heartbeat milestone, the 12 week milestone, the 20 week milestone and we thought that it was finally going to be our turn to bring home a baby. At 22 weeks I had concerns about the baby’s movement and so we booked a scan as a precaution. We found out that the baby’s heart had stopped beating and our whole world fell apart. I delivered our daughter B a few days later and what followed was many months of grieving and hopelessness (and a global pandemic). The results from the postmortem were inconclusive and the NHS tests that I was finally eligible for said that nothing was wrong. Honestly we didn’t know what else to do but try again so we did and suffered another early missed miscarriage.

 

After our fourth loss I had almost given up hope of ever bringing home a healthy baby. I was trying to prepare myself for a life without living children but we decided to try one last thing and that was Mr Shehata’s clinic. I will be forever grateful that we made that decision.

 

Mr Shehata really listened to our story and we felt instantly reassured that this was a doctor who could really help us. He quickly identified that I had too many NK cells with too much activity and Rob had DNA fragmentation all of which could explain our losses. It was such a relief to finally have answers and stop questioning why this was happening to us.

 

It took a while for us to get pregnant again and we ended up using the clinic’s superovulation programme. When we finally fell pregnant again the anxiety that shadowed the pregnancy was crippling. The staff at CRP really held our hands through the whole process. I think I’ve probably cried in front of all of them! We stayed under the clinic for the entirety of the pregnancy and our regular scans with Professor Akolekar played a huge part in reassuring us of our baby’s wellbeing. His scans were extremely thorough and he really took the time to talk us through everything that he was seeing. After 8 long months our miracle was born, a little prematurely but strong and healthy. It felt like there was suddenly light in our life again.

 

Twenty months later and we are now at home with not just one but two beautiful little boys. Our second pregnancy through the clinic was much easier to handle mentally but the anxiety was still there. But this time we knew that the drugs were the answer and that was all we needed to stay positive.

 

Words can’t really describe what the clinic has given us. Their work has completely changed our lives and given us the thing that we wanted most in the world. We will be forever grateful for the work of Mr Shehata and his amazing team and we sing their praises at every opportunity. We heard about the clinic by pure chance through a friend of a friend of a friend who had used them. So we try to tell as many people as we can about the work that they do in the hope of helping other couples going through the unimaginable grief of repeated pregnancy loss.

 

To the team at CRP, a million thank yous,

 

Rob and Ellie

After suffering five recurrent miscarriages and to be told that they were just bad luck, my husband and I decided to seek help for the final time.

 

We researched online, miscarriage specialist, which brought us to Professor Shehata and the CRP Clinic. We thought if there is something causing our miscarriages, Professor Shehata will find it, and didn’t he just.

 

I was diagnosed with elevated natural killer cells and put on a treatment plan which resulted in a successful pregnancy.

 

Our experience at the CRP Clinic was phenomenal from beginning to end and we are forever grateful for making our dream come true.

 

Best wishes,

 

Hannah & Jonny x

We had been trying to have a baby since 2020 and when I was going through my second consecutive miscarriage at 11 weeks I came across Professor Shehata’s name in a podcast. Having had both miscarriages at exactly the same point and having an underlying autoimmune condition, I knew I needed to seek further advice to potentially prevent an unavoidable 3rd miscarriage. 

We booked an initial consultation with Professor Shehata where I finally felt listened to and some of the pains and symptoms I’d been having in the previous pregnancies were validated and taken on board. After having the initial blood tests it appeared that my NK cells were incredibly high and my immune system was attacking the pregnancies. It was a very emotional moment knowing that potentially, the previous miscarriages could have been prevented. 

I was put on a treatment plan which I was initially quite nervous about but Professor Shehata and his team were incredibly reassuring and clearly experts in this field. 

From starting the treatment plan in April 2022, I fell pregnant and our beautiful baby boy Louis was born June 06 2023. It has been a journey to get to this point with a lot of time, road trips and money invested but I truly believe we never would have got here without the help of the CRP. I’ll always be forever grateful that we were able to go down this route and would highly recommend Professor Shehata and his team.

We first visited the CRP clinic in October 2022 after experiencing three miscarriages within the previous year. After feeling underwhelmed by the support available on the NHS and hearing many stories about people being told they had ‘unexplained infertility’ after long waits for NHS testing, we decided we wanted to invest in some private care. We first heard of Dr Shehata on a podcast and he seemed to talk so much sense! It was the first time someone had talked so clearly about issues that sounded so similar to ours and seemed to be able to offer a solution. Despite living in the north of England, we quickly contacted the clinic and were given an initial appointment a couple of weeks later.

 

Three weeks after our first appointment, we returned to the clinic where we were told I had overactive NK cells and too many of them. Dr Shehata presented us with a clear treatment plan and a schedule of appointments to follow as and when we fell pregnant. I had my first intralipid drip that day with a view to trying to conceive when I ovulated that cycle. Miraculously, I ovulated a couple of days later and two weeks after that, we were looking at a positive pregnancy test!

 

Throughout our entire pregnancy, we felt listened to and taken care of and we knew we were in the best possible hands. Although the clinic was a long journey for us, every appointment felt completely worthwhile and was so important in helping us to feel reassured and reduced our anxiety as much as possible after so many previous losses.

 

We were discharged from the clinic at 20 weeks and our beautiful baby boy was born on 17th July 2023 at 39 weeks via a planned c section. Dr Shehata, Ms Silva Edge and Dr Akolakor were all amazing and we can’t thank you enough for finally starting our family.

We started trying to conceive in November 2020 and got pregnant straight away. I was worried cause I had been diagnosed with PCOS years before (no symptoms other than acne) but we were super lucky and got our positive pregnancy test on Christmas Eve 2020.

Sadly we found out we had miscarried on 16th January 2021 (missed miscarriage). We then got pregnant again in March but on the 12th week scan we found out our baby had anencephaly, so I had a D&C to terminate the pregnancy. We were devastated.

By that point we knew we had to do something so we went to a fertility clinic and had all sorts of tests done. Everything came back OK and we were even told that I had no PCOS as far as they could see. So we tried again. And had another missed miscarriage in February 2022.

After this third loss we felt like giving up. We had all possible tests done and were getting no answers. I was desperate to understand what was happening with my body so I read 7 books on pregnancy loss and miscarriage, watched documentaries, researched as much as I could online and talked to other women about possible treatments.

I first read about Prof. Shehata in one of my books. And then started seeing his name everywhere. In podcasts, documentaries and YouTube videos on miscarriages. I knew I had to go see him and his team, so my husband and I had a conversation about money and savings and decided to invest on treatment with the clinic.

We had our first appointment in March 2022. Dr. Shehata and Ms Silva Edge listened to our story and asked for details and explained what kind of tests I would get done. I also left that appointment clearing my doubts about PCOS, as they were able to check it right there and then and it turned out I did have it.

I was put on some medication straight away (metformin) and got blood tests done so we could discuss a plan at my next appointment.

Tests revealed that my body had high levels of NK cells and that it was likely that my immune system was attacking my pregnancies. FINALLY SOME ANSWERS!

They put a plan together for me straight away which consisted of intralipids, adalimumab injections prior to conceiving and prednisolone.

Once we got the green light from them that it was OK to start trying again (in my case it was after 4 adalimumab injections) we got to work and conceived within 2 months. We followed every single step of the treatment to a T, and had scans every 2 weeks with Ms Edge and an anomaly scan with Prof Akolekar. Everything seemed to be going well!! We couldn’t believe how lucky we were as we reached each milestone in our pregnancy.

At 20 weeks we were discharged from the clinic and went into midwifery care under the NHS (I was a bit anxious about this at first as I felt safe at the CRP clinic, it took me a while to get used to it).

We had a very straight forward pregnancy and at 38 weeks + 6 days I went into labour naturally and delivered our sweet baby girl Luna via unplanned C-Section (due to breech presentation). We are so in love with her and can’t believe how lucky we are that we get to be her parents.

The whole team at the clinic is FANTASTIC. The nurses are lovely and so reassuring. We felt welcome from the very beginning. They know how to talk to parents who went through pregnancy loss and are incredibly professional.

We will always be grateful to the CRP for helping us bring this sweet child into the world and we will definitely be back in the future once we’re ready to give Luna a little sibling.

Thank you Dr Shehata and team ❤️❤️

https://www.theguardian.com/commentisfree/2023/apr/14/emotions-infertility-raw-solidarity-fertility-privilege

 

The federal government has announced more than $5 million in grants to better support families in high-risk communities through their grief after a stillbirth or miscarriage. The money, which will be given out during the next three years, will be split between three organisations — Red Nose Australia, Centre for Research Excellence in Stillbirth and Rural Health Connect — to allow them to extend or expand the services they offer to their particular communities.

https://www.abc.net.au/news/2023-04-14/stillbirth-miscarriage-support-high-risk-communities/102219504

 

I honestly can’t thank the CRP Clinic enough.

After 3 consecutive miscarriages, we were losing hope that we would ever become parents. We went to see Mr Shehata soon after our 3rd loss and after some tests he confirmed that I had high levels of natural killer cells and put me on a plan, which ultimately resulted in the birth of our miracle baby girl, who is now 6 months old. Without the help of Mr Shehata, she wouldn’t be here.

It was an emotional rollercoaster of a journey but all of the staff were so supportive. From the caring midwives Laura and Nicola who administered my intralipid injections, to Ms Edge and Geri who were with us when we heard a heartbeat for the first time and were genuinely happy for us, to Prof Ranjit Akolekar who completed our growth scans and was so calm and reassuring throughout the scans.

Thank you all from the bottom of my heart – I still pinch myself that our baby girl is finally here.

I am a past patient of Mr Shehata. Our daughter Selina Isis was delivered in Epsom by him on 23rd December 2011.  We now live in Melbourne and often talk about him with Selina. She has recently been asked to give a short speech at school about how her name was chosen and will no doubt explain that her middle name Isis was chosen because of our link to an Egyptian doctor who brought her safely into the world.

We would like to pass on our deepest thanks and best wishes again, I will never forget the daily visits from our home in Kent to Epsom for scans and check ups, I also clearly remember his visit to my hospital room on Christmas night to check in on me.

I have enclosed pictures of her then and now. She  is such a beautiful person and we are extremely proud of her. She is just staring year 6 at school in Melbourne and has been made a school leader. We come back to the U.K. every summer and I keep thinking will have to bring her over to Epsom.

Best Wishes
Claire

Clinic Fees

  • Initial consultation – £370 (a deductible £100 deposit is required to secure this appointment)
  • Follow up consultation – £210
  • Immune tests – tests range from £160 to £735 each
  • Wellbeing tests – tests range from £65 to £215 each
  • Hormonal tests – tests range from £90 to £260 each
  • Non-invasive Fetal DNA testing – £470
  • Initial scan – £245
  • 3D saline scan – £475
  • HyFosy – £500
  • 3D saline scan + Hyfosy – £655
  • Early pregnancy scans (includes consultation) – £305
  • 3D ultrasound scan (with AFC) – £350
  • Nuchal scan (includes blood tests) – £360
  • Anomaly scan – £360
  • Fetal Medicine scan packages are available on request.

  • Prenatal assessment (11-13 week nuchal and 20-24 fetal anomaly scans – £650
  • Growth scans package (28, 32 and 36 weeks scans) – £900
  • Main Obstetric scans package (11-13 week nuchal, 20-24 fetal anomaly and 34-36 week scans) – £900 
  • Full obstetric scans package (11-13 week nuchal, 20-24 fetal anomaly, 28, 32 and 36 weeks scans) – £1400
  • Comprehensive obstetric scans package (11-13 week nuchal, 20-24 fetal anomaly, 24, 28, 32 and 36 weeks scans) – £1700
  • Manual Vacuum Aspiration (MVA) – from £2,000
  • Hysteroscopy – from £1,365
  • Initial consultation –  £300
  • IVF Returning patient Consultation – £275
  • Pre-IVF scan and consent check for HFEA forms – £350
  • IVF Follow up Consultation – £225
  • IVF cycle –  From £3,950 (excludes initial and nurse consultations medications,  pre-IVF investigation tests)

    IVF packages are available on request
  • Initial consultation – £285
  • Nurse consultation – £200
  • IUI cycle –  From £1,200 (excludes initial and nurse consultations medications,  pre-IUI investigation tests)

    IUI packages are available on request

  • Sperm DNA Integrity – £515
  • Semen Analysis – £235

Procedures

  • Hysteroscopy (no sedation) – £1765

  • Hysteroscopy (sedation) – £1830

  • Operative Hysteroscopy + removal of polyp or adhesion – £3300

  • Operative Hysteroscopy (sedation) – £3435

Clinician Fees

  • Mr Jan Consultation + Ultrasound if required pre-Hysteroscopy – £475

Anaesthetist Fees

  • Dr Shetty – £300

  • Dr Girgis – £250

  • Dr Muddanna – £250

Additional Fees

  • Products of conception (PROC) – £465
  • Cat1 Histology – £237
  • Hyalobarrier Gel + Antibiotics – £300
  • Handling Fees – £35
  • Penthrox – £75

Utrogestan

Utrogestan contains progesterone, which is a natural female sex hormone, produced in the body. It works by adjusting the hormone balance within the body. It is used in different indications related to pregnancy such as IVF and pre-term birth. Recent findings have suggested that women who are at risk of a miscarriage because of current pregnancy bleeding and a history of a previous miscarriage, could also benefit from progesterone treatment.

Given as routine to all women with history of recurrent pregnancy loss or preterm labour.

400mg, oral tablets, started around the time of ovulation until 16 weeks of pregnancy.
In some cases, Utrogestan may be used until 34 weeks.

Should be used with caution with diabetes, epilepsy, hypertension, migraine and cardiac dysfunction.

Bloating, fluid retention, breast tenderness, cramp-like pains due to gastric disturbances and skin irritation, possible menstrual cycle irregularities.

Hydroxychloroquine

Hydroxychloroquine was originally an anti-malaria drug used in the 1940s but more recently has found a place in the treatment of conditions such as Rheumatoid arthritis and Lupus. This is because it has immune properties and seems to calm down inflammation. We have used it against Natural Killer Cells with possible help in women with miscarriages and fertility conditions. There are several publications which have shown its benefit in reducing risk of miscarriages and other immune related complications in pregnancy.

This drug could be considered in complex cases or if there are contraindications to use prednisolone.

300400mg oral tablets. Usually started 4-6 weeks prior to pregnancy. A higher (loading dose) may be required for the first two days of use. The duration of the therapy will be based on individual circumstances.

Neurological disorders (especially in epilepsy), severe gastro-intestinal disorders and G6PD deficiency. Not to be used with azithromycin antibiotics.

Gastro-intestinal disturbances, headache and skin reactions, visual changes, hair loss and pigmentation of the skin, nails and mucous membranes.

You will be required to organise a pre-treatment eye examination and every 6 months whilst taking hydroxychloroquine at your local optometrist. Three monthly wellbeing bloods will be performed.

Most of our patients have tolerated this medication well and it has a good track record in pregnancy with no apparent fetal harm. If you are taking omeprazole, please ensure that you take the two medications at different times as it may inhibit absorption of the hydroxychloroquine.

Intralipid Infusion

Intralipid infusion therapy is a sterile fat emulsion containing soya oil, chicken egg yolk, glycerine and water. The infusion is in liquid form and administered through the veins with an intravenous(IV) cannula*.

The procedure is carried out in the Epsom clinic only as part of your treatment programme. Although not subjected to controlled trials, there are observed benefits in women with miscarriages and fertility conditions.

*Peripheral intravenous (IV) cannulation is an invasive procedure, and risks include phlebitis which may lead to pain or swelling at the infusion site.

Used as part of the treatment programme for high or complex NK cells.

If intralipids are to be included as part of your plan, these will need to be administered
within the CRP Clinic at Epsom where we follow strict clinical guidelines during preparation, administration and delivery of your intralipid therapy to maintain the highest levels of patient safety. Poor safety standards can lead to the introduction of micro-organisms, which may cause infection and other associated risks, including sepsis.

100ml bag of 20% intralipid given as an intravenous dose over 1 hour. The infusion may be required before ovulation, at positive pregnancy test and then repeated every 4 weeks until
20 weeks of pregnancy.

Allergies to Eggs or Soya. Liver disease.

Note: It is important to inform staff if you have had an illness such as a viral infection or diarrhoea and vomiting in the 48 hours prior to your infusion.

Headaches, dizziness, flushing, drowsiness, nausea, vomiting or sweating.
It is rare to have side effects in well patients.

Common side effects we have observed in our patients have included pain/swelling/redness at the infusion site and temperature fluctuations.

Serious side effects (more likely to occur in patients that require this medication on a regular basis for other health issues unlike fertility or miscarriage patients) include: signs of infection (fever, persistent sore throat), injection site reactions (pain, swelling, redness), pain/swelling/ redness of arms and legs, bluish skin, sudden weight gain, shortness of breath, back or chest pain, mental/mood changes, bone pain, muscles weakness, yellowing of skin and eyes, dark urine, bruising or bleeding, severe stomach or abdominal pain.

Omeprazole

This drug belongs to a group called ‘proton pump inhibitors’. They work by reducing the amount of acid that your stomach produces. Omeprazole is mainly used to help reduce the acidic effect of steroids in the stomach.

For patients started on steroids such as Prednisolone, omeprazole is advised to prevent ulcers from forming in the stomach or gut lining.

20mg tablet once a day before breakfast.

Omeprazole is widely used in pregnancy. It is not known to be harmful to an unborn baby.

Headache, effects on your stomach or gut such as diarrhoea, stomach pain or constipation. Nausea and or vomiting.

Fragmin

Fragmin belongs to a group of medicines called low molecular weight heparins, which helps prevent the formation of blood clots by thinning the blood. It is widely used in pregnancy for reducing the risk of blood clots in the mother and in conditions associated with baby growth restriction.

Routinely prescribed in women undergoing treatment with IVF/ICSI and in cases of thrombophilia.

Dose is determined by weight, usually ranging between 5000 and 10 000 units, taken by subcutaneous injections once daily, taken between 6-9pm. Duration of medication is decided on a case-by-case basis.

Manufacturer advises caution in severe hepatic and renal impairment. Not known to be harmful in pregnancy; caution in patients with hypersensitivity to low molecular weight heparins.

Haemorrhage, skin necrosis, low platelets, high potassium, hypersensitivity reactions (including urticaria, angioedema and anaphylaxis); osteoporosis after prolonged use
(and rarely alopecia).

Blood clotting levels ad your full blood count will be checked at 3 monthly intervals.

Prednisolone

Prednisolone belongs to a group of medicines called steroids (corticosteroids). These steroids occur naturally in the body to maintain health and well-being. Boosting your body with extra steroids is an effective way in reducing inflammation. Steroids have widely been used in the treatment of recurrent miscarriage and fertility conditions with varying degrees of success in outcome.

Prednisolone is prescribed to women with recurrent miscarriage or repeated failed assisted conception attempts in the presence of abnormal immune markers such as high NK cells.

The dose usually ranges between 15 and 25mg, and is taken after breakfast. When you have been taking this dose for 3 or more weeks, you will need to wean off the medication by dropping 5mg every 5 days.

Caution is necessary when prescribing prednisolone to patients with the following conditions: adrenal suppression and infection; hypertension, congestive heart failure, liver failure, renal impairment, diabetes mellitus, osteoporosis (post-menopausal women at special risk), glaucoma, psychiatric reactions, severe affective disorders, epilepsy, peptic ulcer, hypothyroidism, history of steroid myopathy.

Prednisolone is compatible with each trimester of pregnancy. Steroids vary in their ability to cross the placenta; 88% of prednisolone is broken down by the placenta and inactivated, therefore very little passes to the baby. There is no evidence that corticosteroids result in an increased incidence of congenital abnormalities, such as cleft palate/lip.

The most common complication is difficulty sleeping at night. Gastrointestinal discomfort, headaches, nausea, altered mood, skin reactions, fatigue, increased weight.

Other Uncommon Side Effects Include

Gastro-intestinal effects include dyspepsia, peptic ulceration, abdominal distension, acute pancreatitis, oesophageal ulceration and candidiasis.

Musculoskeletal effects include proximal myopathy, osteoporosis, vertebral and long bone fractures, avascular osteonecrosis, tendon rupture.

Endocrine effects include adrenal suppression, menstrual irregularities and amenorrhoea, Cushing’s syndrome, hirsutism, weight gain, negative nitrogen and calcium balance, increased appetite, increased susceptibility to and severity of infection.

Neuropsychiatric effects include euphoria, psychological dependence, depression, insomnia, increased intracranial pressure, psychosis and aggravation of schizophrenia, aggravation of epilepsy.

Eye effects include glaucoma, papilledema, posterior subcapsular cataracts, corneal or scleral thinning and exacerbation of ophthalmic viral or fungal disease.

Other side-effects include impaired healing, skin atrophy, bruising, striae, telangiectasia, acne, myocardial rupture following recent myocardial infarction, fluid and electrolyte disturbance, leucocytosis, hypersensitivity reactions, thromboembolism, nausea, malaise, shingles, hiccups.

Further Information: Please be aware that steroids can mask the common symptoms of pregnancy, such as pregnancy sickness.

Wellbeing blood tests are required at 3 monthly intervals.

Aspirin

Aspirin is one of a group of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). It’s widely used to relieve mild to moderate pain and inflammation. It is also widely used in pregnancy for different indications such as reducing the risk of miscarriage, pre-eclampsia, and baby’s growth restriction in women at high risk of these disorders.

In our experience, Aspirin has been shown to reduce the risk of miscarriage, irrespective of outcome of the thrombophilia investigations. It is also used by fertility centres for women undergoing fertility treatment (IVF).

The low dose aspirin we recommend is 75 mg to be taken daily between 6-9 pm after food. Usually, the medication is taken until 20 weeks of pregnancy, but depending on the individual risk of preeclampsia (high blood pressure in pregnancy), the dose may be increased to 150 mg from 12 weeks gestation and continued until 36 weeks.

Not advisable to take if you suffer from asthma, stomach ulcers, known bleeding disorders,
or have mild to moderate renal/hepatic impairment.

Use of low-dose aspirin at any stage of pregnancy has not been associated with harmful effects.

Generally mild and infrequent, but in hypersensitive patients, side effects can include indigestion, heartburn, bloating, gastrointestinal upset with slight asymptomatic blood loss. In severe cases, it can cause an asthma attack and in rare cases, some skin reactions.

GCSF

Granulocyte-Colony Stimulating Factor (G-CSF) is a cytokine (molecules that aid cell-to-cell communication in immune responses and stimulate the movement of cells towards sites of inflammation) that stimulates neutrophilic granulocyte proliferation.

Found to possibly reduce the risk of miscarriage. Based on research trials, G-CSF has been shown to be safe and well-tolerated for mothers throughout pregnancies and for newborns without signs of abnormality. No noticeable side effects were reported.

In certain studies, G-CSF was used in a series of women with unexplained recurrent miscarriage in whom previous treatment with other therapies had failed. It showed G-CSF to be effective in recurrent miscarriage. In one particular study, 29 out of 35 women delivered a healthy baby, whereas in the placebo group, this figure was 16 out of 33. However, further studies are needed to confirm the effectiveness of this treatment in women with unexplained recurrent miscarriage.

The 300 mcg injection is for subcutaneous use. Your doctor will provide instructions on the timing of the injections in line with your treatment plan.

  • Bone pain in areas such as your pelvis, back, arms, or legs.

  • Headache, red or itchy skin (especially around the area where the injection was given).

  • Fever and chills. Over-the-counter painkillers, like paracetamol, can help reduce your temperature and prevent chills.

  • Swelling of the ankles or legs due to fluid retention, which, if severe, could cause breathlessness.

You will need to have a blood test to check your full blood count every 2 weeks whilst on this medication.

Adalimuab

Adalimumab is a TNF blocker, which is used for patients with elevated levels of TNF cytokines or Natural Killer (NK) cells, such as connective tissue disorders. It has been recommended and clinically beneficial in some patients with immune disorders associated with high TNF (tumor necrosis factor) levels.

The women at risk show alterations in CD56+ natural killer cells that secrete tumor necrosis factor. There have been no large studies done on patients with recurrent pregnancy loss or infertility, but several peer-reviewed publications have shown benefit in such conditions.

In cases of high TNF alpha: IL-10 and/or high INF-gamma: IL-10.

Two 40 mg subcutaneous injections: one at a time, 2 weeks apart. Occasionally, this course may be repeated if the TNF alpha: IL-10 or INF-gamma: IL-10 level is still high following the initial two injections.

Predisposition to infection.

Rash, nausea, vomiting, gastric disturbances, infections, headaches, rashes, and shingles.

Adalimumab has been shown not to cause fetal harm and is considered safe in pregnancy if used prior to 32 weeks’ gestation.

  1. If you are satisfied with the information given and have made an informed decision, you will be asked to complete a consent form prior to the arrangement of the prescription.

  2. Once the Adalimumab is received, the first injection can be self-administered, and the other injections stored in the fridge. Adalimumab can be given at any time in your cycle as a subcutaneous injection in the stomach or thigh area.

  3. The second injection is to be administered 2 weeks later.

  4. A further blood test for TNF alpha (HS5) may be needed and arranged after a minimum of 2 weeks following the second injection.

  5. A follow-up appointment is to be made with Professor Shehata 1–2 weeks after the blood test.

All patients, prior to the Adalimumab injections, will have a TB Gold Quantiferon test to ensure that this is negative.

If this is inconclusive, we will need to repeat the test. If TB is positive, then the patient may be referred to a chest physician for assessment and possible tuberculosis treatment prior to receiving the medication.

The TB test takes 5–7 working days to return, after which we will inform you of the result.

Thank You!

Thank you for reaching out to us and completing the enquiry form on our website. We appreciate your interest in our services and understand the importance of this journey for you.

Our team is dedicated to providing you with the support and care you need. One of our specialists will review your enquiry and get back to you to discuss your needs and answer any questions you may have.

We look forward to assisting you and being a part of your journey towards building your family.

Professor Hassan Shehata

Professor Hassan Shehata is a Consultant Obstetrician and Gynaecologist, specialised in Maternal Medicine at Epsom and St. Helier University Hospitals NHS Trust. With an extensive CV, he has contributed his expertise to various hospitals within the UK, building a wealth of experience in obstetrics and gynaecology.

In addition to his diverse clinical background, Professor Shehata is the CEO and Medical Director of the CRP Clinic. He has a wealth of global health contributions including reducing medicalisation of Female Genital Mutilation. He has dedicated his professional life to investigating and treating recurrent miscarriages and addressing challenges associated with failed IVF attempts.